Abstract
Various aspects of muscle strength decrease and loss of motor skills in patients with cerebral palsy (CP) are considered in this review. Pathophysiological mechanisms caused by primary damage and reorganization of central nervous system (CNS), structural-functional changes of muscle tissue, biomechanical disbalance are described. Changes at patients with CP equate with sarcopenia (physiological process of muscle strength and function loss in elderly patients). It has been shown that patients with cerebral palsy have such phenomenon as «early aging» of musculo-skeletal system. Potential approaches for prevention of sarcopenia in children and adults with cerebral palsy are discussed. Understanding of the described mechanisms of primary and age-related changes in muscle tissue in early CNS injuries is necessary to plan the activities of daily living for patients, choose the correct rehabilitation tactics, minimize adverse therapeutic effects, and reasonable management of comorbid conditions.
Highlights
Various aspects of muscle strength decrease and loss of motor skills in patients with cerebral palsy (CP) are considered in this review
Pathophysiological mechanisms caused by primary damage and reorganization of central nervous system (CNS), structural-functional changes of muscle tissue, biomechanical disbalance are described
It has been shown that patients with cerebral palsy have such phenomenon as «early aging» of musculo-skeletal system
Summary
Various aspects of muscle strength decrease and loss of motor skills in patients with cerebral palsy (CP) are considered in this review. Понимание патогенеза мышечной слабости и прогрессирующего ухудшения двигательной функции при ДЦП необходимы для коррекции существующих подходов в реабилитации пациентов детского возраста и максимального сохранения их активности и самообслуживания во взрослой жизни. Нарушение процесса мышечной активации при ДЦП приводит к ограничению возможности точного моторного контроля и произвольной регуляции мышечного усилия [24].
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