Abstract
The aim of this research work was to develop a simple, accurate, sensitive and validated Ultra Violet (UV) spectrophotometric assay using the multivariate regression method for the analysis of Cilnidipine. This multivariate calibration technique was based on equations constructed using linear regression analysis using the correlation between absorbance and concentration at five selected equidistant wavelengths. Cilnidipine had a maximum absorbance at 240 nm. The findings were statistically analyzed for significance. A linear plot in the concentration range of 3-9 μg/mL, with a regression coefficient of 0.999 was obtained. The % RSD for intra-day and Inter-day precision were 0.4558 and 0.6099, respectively. The assay was determined and found to be 99.1% - 101.67% % w/w. Keywords: Cilnidipine, Antihypertensive agent, UV spectrophotometry, Multivariate calibration, Assay, ICH guidelines).
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