Multivariate analysis of pharmacokinetics (PK) and pharmacogenetics (PG) factors following irinotecan (CPT) treatment and the risk of developing neutropenia or diarrhea.

Belén Valenzuela ,V Escudero ,E Martinez-Navarro ,Joseba Rebollo ,Rodrigo González

doi:10.1200/jco.2011.29.15_suppl.e13052

Multivariate analysis of pharmacokinetics (PK) and pharmacogenetics (PG) factors following irinotecan (CPT) treatment and the risk of developing neutropenia or diarrhea.

Belén Valenzuela , V Escudero + Show 3 more

https://doi.org/10.1200/jco.2011.29.15_suppl.e13052

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Journal: Journal of Clinical Oncology

Publication Date: May 20, 2011

#AUC Of SN-38 #Polymorphisms In UDP-glucuronosyltransferase + Show 8 more

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Abstract

e13052 Background: The principal dose-limiting toxicities of CPT are diarrhea and neutropenia related to CPT exposure (AUC of SN-38 and SN-38G). Genetic polymorphisms in UDP-glucuronosyltransferase...

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