Abstract
The influence of vitamin intake on vascular function parameters in the Spanish general population has not been studied. The main objective of this study is to analyze the influence of vitamin intake on vascular function and as a secondary objective the adequacy of vitamin intake in a sample of the Spanish population without previous cardiovascular disease and analyze the differences according to sex. Methods: We included 501 individuals obtained by simple random sampling with replacement (reference population 43,946). The average age was 55.90 ± 14.24 years, 49.70% men. Participants recorded the intake of vitamins using the EVIDENT app, previously validated, during a period of 3 days. Vascular function was assessed by measuring carotid-femoral pulse wave velocity (cfPWV) with the SphygmoCor device, cardio-ankle vascular index (CAVI) with the VaSera device and brachial-ankle pulse wave velocity (baPWV) by using a validated equation. Results: The vitamins with the least adequate intake was vitamin D, less than 5%, and vitamin B9, less than 35%. Vitamins with an adequate intake percentage, close to 100%, were B12 and B6. The multiple regression analysis showed a negative association between cfPWV and vitamin B2 in both sexes, and a positive one with retinol in men and B3 in women. baPWV was negatively associated with vitamins B1 and B12 in women and B9 in men, while being positively linked with B6 in men. CAVI presented a negative association with vitamin D in women. The results were similar in the canonical correspondence analysis. In conclusion, the results of this study suggest that the influence of vitamins on vascular function is not homogeneous and varies according to the parameter analyzed. Thus, in men, vitamins B2 and retinol were associated with cfPWV and vitamins B6 and B9 with baPWV. In women, vitamins B2 and B3 were related cfPWV, vitamins B1 and B12 with cfPWV and vitamin D with CAVI.
Highlights
Arterial stiffness is a manifestation of subclinical organic damage linked to ageing and provides an established marker of cardiovascular disease [1]
Numerous studies have found that the increase in different measures of arterial stiffness, such as the speed of the carotid-femoral pulse wave velocity, brachial-ankle pulse wave velocity and the cardio-ankle vascular index (CAVI)
For every meter-per-second increase in carotid-femoral pulse wave velocity (cfPWV), the risk adjusted for age, sex and cardiovascular risk factors increased by 14% for total cardiovascular events, and 15% for cardiovascular mortality and all-cause mortality [5]
Summary
Arterial stiffness is a manifestation of subclinical organic damage linked to ageing and provides an established marker of cardiovascular disease [1]. CfPWV is considered the “gold standard” as a measure of arterial stiffness from the carotid artery to the iliac, reflecting the stiffness in the aorta, and increases with age and blood pressure [6]. CAVI estimates arterial stiffness from the heart to the ankle It is considered an index of central and peripheral arterial stiffness independent of blood pressure at the time of measurement [10] and can be used as a marker of atherosclerosis and an indicator of lifestyle modification [10,11]. Vitamins are organic compounds necessary for human metabolism They are involved in proper growth, in the development of the nervous, immune, bone and skin systems.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
