Abstract
A functional study has been performed to characterise the Y receptors responsible for NPY, PYY and PP-stimulated responses in mouse colonic mucosal preparations. Electrogenic ion secretion was stimulated with VIP following which NPY, PYY and PP analogues were, to varying degrees, inhibitory. PYY(3-36), hPP, Gln 23hPP and rPP were effective but less potent than full length PYY, NPY or their Pro 34-substituted analogues, while the Y 5 agonist Ala 31, Aib 32hNPY was the least active peptide tested. The Y 1 antagonists, BIBP3226 and BIBO3304 virtually abolished Pro 34PYY and PYY responses while PYY(3-36) responses were selectively inhibited by the Y 2 antagonist, BIIE0246. A combination of BIBO3304 and BIIE0246 also partially attenuated hPP responses, leaving residual effects that were most probably Y 4-mediated. Thus we conclude that Y 1, Y 2 and Y 4 receptors attenuate ion secretion in mouse colon.
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