Abstract
After split-dose irradiation, pre-lymphoma cells develop from a tumor-specific surface antigen TL-2 + thymocyte subpopulation. To analyze the clonality of pre-lymphoma cells, various numbers of TL-2 + thymocytes from a single irradiated mouse were intra-thymically injected to Thyl congenic recipient mice. The incidence of donor type thymic lymphoma(s) was subsequently examined in a group of recipient mice. We chose several lymphomas derived from a single donor mouse and analyzed the TCR gene rearrangements and V(D)J junctional diversity as genetic markers of clonality. These results indicate multiple initial neoplastic events and clonal selection into lymphoma.
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