Abstract
Helicobacter pylori causes human gastroduodenal diseases, including chronic gastritis and peptic ulcer disease. It is also a major microbial risk factor for the development of gastric adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma. Twenty-one strains with different ethnicity, disease, and antimicrobial susceptibility backgrounds were sequenced by use of Illumina HiSeq and PacBio RS platforms.
Highlights
Twenty-one strains with different ethnicity, disease, and antimicrobial susceptibility backgrounds were sequenced by use of Illumina HiSeq and PacBio RS platforms
Together with 10 previously announced genome sequences [6], which have been reassembled using newer algorithms, we present here 21 genome sequences of H. pylori strains isolated from patients with different ethnicities, disease statuses, and antimicrobial susceptibility patterns who were attending the endoscopy unit at the University of Malaya Medical Center (UMMC) (Table 1)
De novo assembly of the read sequences was carried out using continuous long reads (CLR) following the Hierarchical Genome Assembly Process (HGAP) workflow (PacBio DevNet; Pacific Biosciences) as available in single-molecule real-time (SMRT) Analysis v2.0
Summary
Helicobacter pylori causes human gastroduodenal diseases, including chronic gastritis and peptic ulcer disease. Twenty-one strains with different ethnicity, disease, and antimicrobial susceptibility backgrounds were sequenced by use of Illumina HiSeq and PacBio RS platforms. Clinical outcomes induced by Helicobacter pylori vary with individuals [1], especially among those with different ethnic origins [2].
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