Abstract
Two classes of dopamine receptor mechanism are defined according to their association with, or independence from, a dopamine-sensitive adenylyl cyclase. Dopamine receptors unrelated to adenylyl cyclase are designated type alpha. Dopamine receptors linked to adenylyl cyclase are designated type beta. Drugs discriminate between the two receptor mechanisms. The dopaminergic ergots (lisuride, lergotrile and CB-154) and their antagonists (such as metoclopramide) are relatively specific for the alpha-dopaminergic receptor in the anterior pituitary. Other agonists (e.g. apomorphine and dopamine) and antagonists (e.g. antipsychotic phenothiazines and butyrophenones) affect both classes of receptor.
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