Abstract
Although giant cell lesions occur as single lesions, they can occur multifocally and in association with syndromes. A 14-year-old male patient presented an asymptomatic swelling in the right mandible. Panoramic radiography and computed tomography (CT) showed a single, multiloculated, radiolucent/hypodense lesion in right mandibular body and ramus, affecting the coronoid process. Incisional biopsy confirmed the diagnosis of giant cell lesion, and parathyroid hormone, calcium, phosphorous, and alkaline phosphatase levels excluded hyperparathyroidism. The lesion was unresponsive to conservative treatment with intralesional corticoid injections, and total enucleation with peripheral osteotomy and Carnoy's solution was performed. A 10-month follow-up CT showed another lesion in the left mandibular body, which microscopically was confirmed as a giant cell lesion. These multiple giant cell lesions in a young patient are compatible with the diagnosis of a mild and atypical manifestation of cherubism or another syndromic condition. Further genetic analysis might help clarify such assumptions.
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