Abstract
An optical stimulation shows various effects for skin regeneration and wound treatment by using different wavelength. Similarly, ultrasound stimulation can improve skin wrinkles and contours by inducing the contraction and synthesis of collagen to reduce local fat accumulation. In this study, using commercially available light-emitting diodes (LEDs) for skin regeneration masks (415 nm, 630 nm, 850 nm), a single wavelength and multiple wavelengths were applied to fibroblast cells in various ways to control the proliferation effect of skin cells. In addition, ultrasonic stimulation was applied simultaneously to quantitatively evaluate the proliferation effect of fibroblasts. As a result, it was confirmed that there was an effect on fibroblast cell proliferation when the LED light stimulation of a specific wavelength was applied, and also the proliferation activity of skin cells increased even in the multimodal stimulation by applying a combination of LEDs and ultrasound.
Highlights
In recent years, interest in personal skincare systems has been increasing as the population ages and the number of SNS user increases
Multimodal stimulation groups were divided into three groups (Group D (R+ US), E (IR + R + B + US), F (IR + R + R + US) to apply the LED and US stimulation at the same time in the same position. 3D printer (Cubicon DP-310F, Korea Cubicon Co., Ltd.) was used to make a LED stimulation supporter so that cells can be stimulated in the center of each well of the plate
Representative images of the experimental group and the control group were obtained after stimulation application through an optical microscope
Summary
Interest in personal skincare systems has been increasing as the population ages and the number of SNS user increases. There are limitations that laser, which are relatively expensive and inconvenient to use, can cause thermal destruction of effective tissues due to the high heat generated, so LED that are relatively low cost among various light stimuli and have a high degree of freedom of choice are widely used [1,2] For this reason, related research is actively conducted to quantitatively evaluate skin regeneration effects using LEDs. For example, the effect on skin cells by LED varies depending on the light characteristics such as exposure light intensity, wavelength, and exposure time [3,4]. After conducting a simultaneous application experiment with the sole application of light stimulation and ultrasonic stimulation, the images were obtained through a microscope to show its significance
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