Multifunctional Logic in a Photosensitizer with Triple-Mode Fluorescent and Photodynamic Activity.

Abstract

Herein we describe a photosensitizer (PS) with the capacity to perform multiple logic operations based on a pyrene-containing phthalocyanine (Pc) derivative. The system presents three output signals (fluorescence at 377 and 683 nm, and singlet oxygen ((1)O2) production), which are dependent on three inputs: two chemical (concentration of dithiothreitol (DTT) and acidic pH) and one physical (visible light above 530 nm for (1)O2 sensitization). The multi-input/multioutput nature of this PS leads to single-, double-, and triple-mode activation pathways of its fluorescent and photodynamic functions, through the interplay of various interrelated AND, ID, and INHIBIT gates. Dual fluorescence emissions are potentially useful for orthogonal optical imaging protocols while (1)O2 is the main reactive species in photodynamic therapy (PDT). We thus expect that this kind of PS logic system will be of great interest for multimodal cellular imaging and therapeutic applications.