Abstract
The current study was carried out to evaluate multicomponent pattern, biological and enzymatic activities of seven Asphodeline taxa root extracts as useful ingredients, due to the fact that these plants are commonly used as traditional food supplements in Turkish regions. The extracts were characterized for free anthraquinones and phenolics to obtain a specific chemical fingerprint useful for quality control. These analyzes were coupled to biological and enzymatic activities in order to obtain comprehensive information of the natural product. Free anthraquinones and phenolics were determined using validated HPLC-PDA methods. Antioxidant properties were determined by different procedures including free radical scavenging, reducing power, phosphomolybdenum and metal chelating assays. Ames assay was performed to evaluate mutagenic/antimutagenic properties. Enzyme inhibitory activities were tested against cholinesterase, tyrosinase, α-amylase and α-glucosidase. From the herein reported results, Asphodeline could be valuable for the production of bioactive products or food supplements for cosmetic and pharmaceutical industries.
Highlights
In many industrial fields the easy availability of natural derivatives can be very helpful in order to produce food supplements and/or natural products that can be used to obtain beneficial effects on human health
In continuation to our studies on natural products analyzes[15,16,17,18,19,20,21,22,23,24] and instrument configurations[25,26,27,28], we report for the first time the free anthraquinones and phenolics pattern, biological activities (ABTS, DPPH, CUPRAC, ferric ion reducing antioxidant power (FRAP), phosphomolibdenum, metal chelating, and Ames assays), enzyme inhibitory activities
The total phenolic contents of the Asphodeline extracts were detected by Folin-Ciocalteu assay
Summary
In many industrial fields the easy availability of natural derivatives can be very helpful in order to produce food supplements and/or natural products ( in combination) that can be used to obtain beneficial effects on human health. Across history and cultures, have been used for medicinal purposes as alternative therapies based on plants in order to avoid drug adverse effects, and over the past years, many articles were reported To avoid this last drawback and, to obtain alternative biologically active products, an increased interest in natural products (or natural-like products) was observed[1,2]. The methods used in plant material extraction can influence the chemical composition of the resulting extracts and potentially the biological activity[3,4] For these reasons, the actual challenge is to fully understand and characterize botanical preparations as “multicomponent pattern” in the context of modern food and health system in which consumers are often uneducated about the use and effective applications of these supplements[5]. The Food and Drug Administration (FDA) specifies certain labeling requirements for foods, supplements, and drugs, and the European Union requires that standardized herbal substances are reported as content of constituents with known therapeutic activity
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