Abstract

The nitrogen(N)-sulfur(S)-sodium(Na(I)) co-doped carbon quantum dots (CQDs) were synthesized via a one-step hydrothermal method, which exhibited a remarkably high fluorescence quantum yield (24.58%) and exceptional optical properties. The fluorescence “on-off-on” sensor was constructed. The fluorescence of CQDs was rapidly quenched with Fe(III) and the fluorescence recovered by ascorbic acid (Asc) partially and arginine (Arg)/histidine (His) completely. The CQDs fluorescence sensor demonstrated rapid response, exceptional sensitivity, excellent stability, remarkable selectivity, and robust anti-interference performance, which was feasible to simultaneously determine the concentrations of multiple analytes in the sample with satisfactory recovery rates. The “on-off-on” fluorescence mechanism of CQDs was investigated, revealing the significant potential of carbon nano-functionalized materials in the field of drug detection through fluorescence sensing.

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