Abstract
Zearalenone (ZEN) is a low-weight molecule toxin which can cause great damage to human health. A multicolor immunosensor for determination of ZEN was developed based on etching gold nanobipyramids (Au NBPs) mediated by horseradish peroxidase (HRP). In this new immunosensor, the anti-ZEN monoclonal antibody (McAb) induced the formation of ternary immunocomplex BSA-ZEN@McAb@HRP-IgG. Then, TMB was converted to TMB+ under the catalysis of HRP. Subsequently, TMB+ reacted with H+ to form TMB2+. Finally, the Au NBPs was etched by TMB2+ to produce blue shift of longitudinal absorption peaks of Local Surface Plasmon Resonance (LSPR). Meanwhile, the solution exhibited different multiple colors, which can be recognized by the naked eyes. Under the optimal conditions, the limit of detection of this new immunosensor was 0.011 ng/mL, whose linear range was 0.02 ~ 0.80 ng/mL. Besides, this new immunosensor had good sensitivity for ZEN and potential application prospect.
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