Multi−Enzyme Complex for the Management of Delayed Onset Muscle Soreness after Eccentric Exercise: A Randomized, Double Blind, Placebo Controlled Study

Abstract

Background: Delayed onset muscle soreness (DOMS) results from muscle overload or strenuous exercise that goes beyond the intensity or duration for which the muscle is accustomed to performing. It is accompanied with the sensation of pain, tenderness, deep ache, and stiffness in muscles that usually begins several hours after the unaccustomed exercise. The aim of this study was to compare the efficacy of multi enzyme complex with a matching placebo in reducing pain associated with DOMS induced by standardized eccentric exercise. Methods: Twenty healthy males (10 pairs) were randomized in this double blind, placebo controlled trial to receive a placebo or multi enzyme complex capsule (50 mg) thrice a day for a period of 3 days. Mean differences within the group and between groups were assessed at each data collection time-point using Analysis of Covariance (ANCOVA) and Wilcox on signed rank sum test for all outcome measures. Results: In this controlled clinical study, intake of multi enzyme complex for 3 days resulted in no statistically significant changes in the descriptive statistics and efficacy analysis in muscle power and grip strength measured by hand held dynamometer. Algometer readings of thigh muscle, showed statistical significance (p<0.043). Decrements were observed in McGill Pain Questionnaire showing high statistical significance. Reducing trend was observed in bio markers of muscle damage (creatine kinase and lactate dehydrogenase) as well. Conclusion: The study results suggest that compared to placebo, Multi enzyme complex supplementation improves the outcome measures related to DOMS induced by standardized eccentric exercise.