Abstract
The suitability of total-reflection X-ray fluorescence analysis (TXRF) for multi-element determination in whole blood and human serum has been investigated. In combination with microwave digestion with nitric acid the elements P, S, K, Ca, Fe, Cu, Zn, Se, Rb, Sr, and Pb were determined in samples from several patients. The detection limits for heavy metal traces are in the range of 0.02 –0.08 μg/ml, the precision is in the range of 2 –10%. The elements Mn, Ni and Pb could additionally be determined after iron-(only necessary for whole blood) and salt-matrix separation. In this way the detection limits could be improved by more than one order of magnitude (0.002 μg/ ml). The accuracy of the results and the reliability of the analytical procedures are checked with the help of several certified reference materials. In general the accuracy is in the range of 2–15%.
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