Abstract
The mammalian STE20-like (MST) protein kinases are composed of MST1, MST2, MST3, MST4 and YSK1. They play crucial roles in cell growth, migration, polarity and apoptosis. Dysfunction of these kinases often leads to diseases. MST kinases are extensively involved in development and function of immune system. Here, we review recent progresses on the regulatory function of MST kinases in innate immune signaling.
Highlights
The mammalian STE20-like (MST) kinases are evolutionarily conserved homologues of yeast Sterile20 (STE20) kinase [1]
The GCKII subfamily consists of MST1 and MST2; the GCKIII subfamily consists of MST3, MST4 and YSK1
MST kinases are emerging as crucial regulators of innate immune response
Summary
The MST kinases are evolutionarily conserved homologues of yeast Sterile20 (STE20) kinase [1]. SAV1 and MOB1A/B, MST1/2 can activate downstream kinases LATS1/2, leading to the phosphorylation and inhibition of the transcriptional coactivators YAP and TAZ. STRN proteins recruit PP2A to negatively regulate the functions of MST kinases in cell growth and cancer metastasis most likely via dephosphorylating these kinases and inhibition of their kinase activities [23, 28].
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