Abstract
The biological profile of sodium selenosulfate, Na(2)SeSO(3), is still largely unknown. The present study found that sodium sulfite reacted with elemental selenium at nanoparticle size already at 37 degrees C to yield sodium selenosulfate. Additionally, selenosulfate was obtained by mixing sodium selenite, glutathione, and sodium sulfite at room temperature. In vitro, sodium selenosulfate killed HepG2 or Caco2 cells, in a dose-dependent fashion, and 12.5 microM fully suppressed their proliferation. In addition, sodium selenosulfate showed a consistent cytotoxic effect when added to three kinds of leukemia cell lines (HL60, T lymph adenoma, and Daudi).
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