Abstract
This present study was aimed to investigate the roles of the receptors of Th1/Th2 cytokines and chemokines in the pathogenesis of chronic idiopathic urticaria (CIU). Thirty patients with CIU, 30 patients with dermographism and 30 healthy controls were randomly enrolled. Reverse transcription-PCR (RT-PCR) was used to analyze the mRNA of cytokine receptors in peripheral blood mononuclear cells (PBMCs). The mRNA levels of tumor necrosis factor receptor ( TNFR), interferon-γ receptor ( IFN-γR), and interleukin-10 receptor ( IL-10R) were statistically increased in the CIU group ( P < 0.05), while IL-2R, IL-4R, IL-6R, and IL-13R showed no significant differences between the CIU and other groups. The mRNA levels of CCR3 and CCR6 were statistically increased in the CIU group ( P < 0.05). The toll-like receptor 2 ( TLR2) mRNA level was significantly lower in the CIU group than the healthy control group ( P < 0.05). These findings indicate that the regulation of mRNA of TNFR, IFN-γR, IL-10R, CCR3, CCR6 and TLR2 may be involved in the pathogenesis of CIU.
Highlights
Chronic idiopathic urticaria (CIU) is a chronic inflammatory skin disease characterized by short-lived, pruritous swellings of the skin, mouth, and genitalia due to transient leakage of plasma from small blood vessels into the surrounding connective tissue
We examined the expression profiles of cytokine receptors in the peripheral blood mononuclear cells (PBMCs) of chronic idiopathic urticaria (CIU) patients to investigate the possible actions of the receptors of Th1/Th2 cytokines and chemokines in the pathogenesis of CIU
The mRNA expression of Th1/Th2 cytokine receptors in unstimulated PBMCs was detected in all the subjects
Summary
Chronic idiopathic urticaria (CIU) is a chronic inflammatory skin disease characterized by short-lived, pruritous swellings of the skin, mouth, and genitalia due to transient leakage of plasma from small blood vessels into the surrounding connective tissue. The etiology and pathogenesis of CIU are complicated and still remain to be elucidated[1]. The histopathological lesions of the skin in CIU is usually marked by dermal edema, and perivascular mononuclear cell infiltration predominantly with lymphocytes, eosinophils and mast cells. The actions of these infiltrating lymphocytes in the pathogenesis of CIU as well as the linkage between the infiltrating lymphocytes and other inflammatory cells in CIU are not fully delineated so far.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
