Abstract
The degree of muscle involvement of lower leg muscles of 34 patients with DMD >8 years, using muscle MRI, was estimated in a multicenter study at the Institute of Child Health and other centers in London, in the UK, and 1 in Rome, Italy.
Highlights
The degree of muscle involvement of lower leg muscles of 34 patients with DMD >8 years, using muscle MRI, was estimated in a multicenter study at the Institute of Child Health and other centers in London, in the UK, and 1 in Rome, Italy
A mathematical model to predict serum ALT and AST levels with known CPK and age was developed to provide reassurance that elevated transaminase may be indicative of muscle disease, avoiding unnecessary tests of liver dysfunction
The study was prompted by the observed reluctance of clinicians to attribute high transaminase levels to muscle disease, leading to delayed diagnosis and extensive tests for liver dysfunction
Summary
Researchers at Children's Hospital Boston, MA, have shown a linear relationship between serum CPK and serum ALT and AST and a logarithmic relationship between serum enzyme levels and age for boys with Duchenne (n=46) or Becker (n=9) muscular dystrophy (DMD or BMD). A mathematical model to predict serum ALT and AST levels with known CPK and age was developed to provide reassurance that elevated transaminase may be indicative of muscle disease, avoiding unnecessary tests of liver dysfunction. The study was prompted by the observed reluctance of clinicians to attribute high transaminase levels to muscle disease, leading to delayed diagnosis and extensive tests for liver dysfunction. Serum transaminase levels in boys with Duchenne and Becker muscular dystrophy.
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