Abstract
The purpose of this study was to evaluate which radiological depth of invasion (r-DOI) measurement is the most concordant to clinical DOI (c-DOI) derived from correction for the shrinkage rate of the histopathological specimens. We retrospectively reviewed 128 patients with tongue carcinoma who had undergone glossectomy between 2006 and 2019. At first, the width shrinkage rate during formalin fixation and preparation process of histopathological specimens was evaluated. From the shrinking rates, a formula to calculate c-DOI from pathological DOI (p-DOI) was developed. The correlation between c-DOI and r-DOI was evaluated. The specimen shrinkage rate during the histopathological specimen preparation process was 10.3%. Based on that, we yielded the correct formula for c-DOI based on p-DOI and preparation shrinkage rate: c-DOI = p-DOI × 100/89.7. The regression equations for the association of c-DOI with r-DOI measured by ultrasound (n = 128), MRI before biopsy (n = 18), and MRI after biopsy (n = 110) were y = 1.12 * x + 0.21, y = 0.89 * x − 0.26, and y = 0.52 * x + 2.63, respectively, while the coefficients of determination were 0.664, 0.891, and 0.422, respectively. In conclusion, r-DOI using MRI before biopsy most strongly correlated with c-DOI.
Highlights
The purpose of this study was to evaluate which radiological depth of invasion (r-DOI) measurement is the most concordant to clinical DOI (c-DOI) derived from correction for the shrinkage rate of the histopathological specimens
Previous studies have reported significant relationship between r-DOI measured on these modalities and pathological DOI (p-DOI) in the tongue SCC8–12. r-DOI differs from the tumor thickness (TT), and is defined as the distance from a virtual normal mucous membrane to the tumor’s deepest part on the image
While surgical margins in head and neck cancer specimens shrink after formalin fixation, specimens were fixed by pins during formalin fixation in this study
Summary
The purpose of this study was to evaluate which radiological depth of invasion (r-DOI) measurement is the most concordant to clinical DOI (c-DOI) derived from correction for the shrinkage rate of the histopathological specimens. Abbreviations DOI Depth of invasion c-DOI Clinical depth of invasion r-DOI Radiological depth of invasion p-DOI Pathological depth of invasion TT Tumor thickness SCC Squamous cell carcinoma. CT, MRI, and ultrasound, which can demonstrate the location of the tumor, are widely used in tongue squamous cell carcinoma (SCC). Another problem is the deviation of 1.2–3 mm between r-DOI and p-DOI in tongue c arcinoma[7,8,9] because the width shrinkage rate during the preparation process of histopathological specimen was not considered. The purpose of this study was to evaluate which r-DOI measurement is the most concordant to clinical DOI (c-DOI) determined from p-DOI corrected for shrinkage
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