MPS 04-05 THE ASSOCIATION BETWEEN PLASMA ALDOSTERONE CONCENTRATION /PLASMA RENIN ACTIVITY AND PULSE PRESSURE IN NEVER-TREATED HYPERTENSIVE PATIENTS; 24 HOURS AMBULATORY BLOOD PRESSURE MONITORING STUDY

Abstract

Objective: Reduction of vascular compliance leads to an increment of afterload on the heart (as lower arterial compliance is closely related to increased pulse pressure), which in turn leads to left ventricular hypertrophy and diastolic dysfunction. Plasma aldosterone concentration (PAC) are influenced by a number of factors, including potassium and volume status. Design and Method: This study aimed to examine the association the association between PAC/plasma renin activity (ARR) and pulse pressure in Never-Treated Hypertensive Patients. This prospective study included a total of 314 patients (mean age: 52.0 ± 12.2 years; 55.0 % male) with never-treated essential hypertension. We collected the data from 24-hour ambulatory BP, Echocardiography, pulse wave velocity, ankle brachial index, PAC, and plasma renin activity (PRA) from all of the patients. Results: The measured pulse pressure from 24 hours ambulatory BP monitoring was correlated with E/E′ (r = 0.149, P = 0.012) and LA volume index (r = 0.308, P < 0.001). However, there are negative associations between pulse pressure and PAC levels (r = −0.145, P = 0.032). Conclusions: Pulse pressures in never-treated hypertensive patients were closely correlated with diastolic dysfunctions and inversely correlated with PAC. Relative low PAC could be caused by high salt intake and volume overload. Pulse pressure could be a surrogate marker of diastolic dysfunction and volume overload including high salt intake in never treated hypertensives.