MP79-04 MEASUREMENT OF PROSTATE CANCER-ASSOCIATED ABERRANT GLYCOSYLATION OF PROSTATE SPECIFIC ANTIGEN CAN IMPROVE DIAGNOSTIC ACCURACY

Abstract

6; and intermediate risk included biochemical recurrence and Gleason 7 disease. Logistic regression analysis was used to examine the association between allele counts and tumor aggressiveness. Separate analyses were performed by race (European ancestry and African American) and Gleason score. RESULTS: Case-case analyses of men of European ancestry with highor low-risk disease showed that 12 SNPs were over-represented in men with highcompared to low-risk disease in an unadjusted analysis. Only 3 SNPs were demonstrated similar associations in African American men. Multivariate models that corrected the presence of the other SNPs showed that only SNP rs2735839 on 19q13.3 remained significant in both races (p<0.0001). A separate case-case analysis comparing Gleason score 8 to low-grade disease demonstrated that 13 and 6 SNPs were associated with Gleason score in both Europeans and African Americans, respectively. Again, multivariate analysis revealed only SNP rs2735839 remained significantly associated with Gleason grade. CONCLUSIONS: Many validated PC risk SNPs, including rs2735839, demonstrate an association with disease aggressiveness in both men of European and African American ancestry. However, future genome wide association studies involving men with highand low-risk disease are required to identify novel SNPs that can also be used to identify men most at risk of life-threatening disease.