MP75-03 A PROSPECTIVE RANDOMIZED OPEN-LABEL CLINICAL OBSERVATIONAL STUDY TO ASSESS THE EFFECTIVENESS OF ADDING TAMSULOSIN IN WOMEN TREATED WITH SOLIFENACIN FOR OVERACTIVE BLADDER

Abstract

You have accessJournal of UrologyUrodynamics/Incontinence/Female Urology: Female Urology II1 Apr 2014MP75-03 A PROSPECTIVE RANDOMIZED OPEN-LABEL CLINICAL OBSERVATIONAL STUDY TO ASSESS THE EFFECTIVENESS OF ADDING TAMSULOSIN IN WOMEN TREATED WITH SOLIFENACIN FOR OVERACTIVE BLADDER Changhee Yoo, Sun Il Kim, Jae Hyun Bae, Jung Hwan Son, Cheol Young Oh, Dong Hee Yoon, Seoung Yul Lee, Seoung-Ju Lee, Sung Jin Chung, Young Kwon Hong, Jong Bo Choi, and Woo Jin Bang Changhee YooChanghee Yoo More articles by this author , Sun Il KimSun Il Kim More articles by this author , Jae Hyun BaeJae Hyun Bae More articles by this author , Jung Hwan SonJung Hwan Son More articles by this author , Cheol Young OhCheol Young Oh More articles by this author , Dong Hee YoonDong Hee Yoon More articles by this author , Seoung Yul LeeSeoung Yul Lee More articles by this author , Seoung-Ju LeeSeoung-Ju Lee More articles by this author , Sung Jin ChungSung Jin Chung More articles by this author , Young Kwon HongYoung Kwon Hong More articles by this author , Jong Bo ChoiJong Bo Choi More articles by this author , and Woo Jin BangWoo Jin Bang More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.2376AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES To verify additional effect of alpha-blocker to anticholinergics in women with overactive bladder (OAB). METHODS 144 women (age¡Ã18 years) were enrolled. They complained OAB symptoms with International Prostate Symptom Score ¡Ã 8 and OAB short symptom score (OABSS) ¡Ã 2 in Q3 with over 3 of total OABSS and frequency more than 8 a day on voiding diary. Any subjects with neurogenic bladder, previous pelvic operation history and urinary tract infection were excluded. They were randomly assigned to solifenacin monotherapy (Mono) group (n=71) or solifenacin and tamsulosin combination therapy (Comb) group (n=73). The primary end points were change of frequency and urgency episode in voiding diary at 4 and 12 weeks after treatment. RESULTS In the Mono group, 65 and 56 women completed the protocol at 4 and 12 weeks respectively. And, in the Comb group, 56 and 49 women completed the protocal at 4 and 12 weeks respectively. At 4 weeks, the change of mean frequency, and the change of mean urgency episode were significantly larger in the Comb group.(p=0.027, and p=0.048 respectively). However, at 12 weeks, only the change of mean urgency episode was significantly larger in the Comb group (p=0.046). (Table 1) CONCLUSIONS Tamsulosin and solifenacin combination treatment improved OAB symptoms more rapidly than solifenacin monotherapy. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e874 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Changhee Yoo More articles by this author Sun Il Kim More articles by this author Jae Hyun Bae More articles by this author Jung Hwan Son More articles by this author Cheol Young Oh More articles by this author Dong Hee Yoon More articles by this author Seoung Yul Lee More articles by this author Seoung-Ju Lee More articles by this author Sung Jin Chung More articles by this author Young Kwon Hong More articles by this author Jong Bo Choi More articles by this author Woo Jin Bang More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...