MP72-11 OPTIMAL MANAGEMENT FOR INITIALLY DIAGNOSED TA HIGH GRADE BLADDER CANCER. WHAT DOES MATTER FOR INTRAVESICAL RECURRENCE?

Abstract

You have accessJournal of UrologyBladder Cancer: Non-invasive III (MP72)1 Apr 2020MP72-11 OPTIMAL MANAGEMENT FOR INITIALLY DIAGNOSED TA HIGH GRADE BLADDER CANCER. WHAT DOES MATTER FOR INTRAVESICAL RECURRENCE? Tetsuya Shindo*, Atsushi Takahashi, Kohei Hashimoto, Toshiaki Tanaka, Naoki Itoh, Manabu Okada, Hiroshi Hotta, Yasuharu Kunishima, Takaoki Hirose, Masanori Matsukawa, Hitoshi Tachiki, Kato Ryuichi, and Naoya Masumori Tetsuya Shindo*Tetsuya Shindo* More articles by this author , Atsushi TakahashiAtsushi Takahashi More articles by this author , Kohei HashimotoKohei Hashimoto More articles by this author , Toshiaki TanakaToshiaki Tanaka More articles by this author , Naoki ItohNaoki Itoh More articles by this author , Manabu OkadaManabu Okada More articles by this author , Hiroshi HottaHiroshi Hotta More articles by this author , Yasuharu KunishimaYasuharu Kunishima More articles by this author , Takaoki HiroseTakaoki Hirose More articles by this author , Masanori MatsukawaMasanori Matsukawa More articles by this author , Hitoshi TachikiHitoshi Tachiki More articles by this author , Kato RyuichiKato Ryuichi More articles by this author , and Naoya MasumoriNaoya Masumori More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000952.011AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: According to 2004 ISUP/WHO classification, Ta high grade (TaHG) bladder cancer (BCa) are increasing. Thus, to evaluate optimal treatment options for initially diagnosed TaHG BCa, we performed multicenter retrospective study. METHODS: We retrospectively collected clinical data of initially diagnosed TaHG BCa patients from 10 hospitals. All patients underwent transurethral resection (TUR) from January 2007 through October 2018. Finally, 314 TaHG patients without history of prior BCa were included. The primary end point was intravesical recurrence and the secondary end point was the predictive factor for intravesical recurrence. The study was approved by the institutional review board (No. 302-162). RESULTS: The follow up period for the cohort was 37.4 ± 26.3 (mean ± SD) months and 122 patients (38.9%) underwent second TUR. Among 314 patients, 170 patients (54.1%) underwent immediate intravesical instillation of anticancer agent and 218 patients (69.4%) underwent induction intravesical instillation of anticancer agent such as anthracycline chemotherapy or mitomycin-C, Bacillus Calmette–Guérin (BCG) and 92 patients (29.3%) had intravesical recurrence. Immediate intravesical instillation and induction intravesical instillation therapy for initially diagnosed TaHG BCas were key treatment to prevent intravesical recurrence. On the contrary, second TUR had no impact (Table 1). Subgroup analysis according to number of these treatment options was shown in Figure 1. Moreover, interestingly, among patients who treated by BCG or the other intravesical chemotherapeutic agent, there was no difference for intravesical recurrence (P = 0.827, Log-rank test). CONCLUSIONS: Our results suggest that immediate and induction intravesical instillation were important strategy for patients with initially diagnosed TaHG BCa to prevent intravesical recurrence. Moreover, intravesical BCG and second TUR may not be essential for these patients. Source of Funding: none © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e1077-e1078 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Tetsuya Shindo* More articles by this author Atsushi Takahashi More articles by this author Kohei Hashimoto More articles by this author Toshiaki Tanaka More articles by this author Naoki Itoh More articles by this author Manabu Okada More articles by this author Hiroshi Hotta More articles by this author Yasuharu Kunishima More articles by this author Takaoki Hirose More articles by this author Masanori Matsukawa More articles by this author Hitoshi Tachiki More articles by this author Kato Ryuichi More articles by this author Naoya Masumori More articles by this author Expand All Advertisement PDF downloadLoading ...