MP66-19 PREDICTIVE VALUE OF INFLAMMATION-BASED PROGNOSTIC SCORES IN PATIENTS WITH METASTATIC RENAL CELL CARCINOMA TREATED WITH CYTOREDUCTIVE NEPHRECTOMY

Abstract

You have accessJournal of UrologyKidney Cancer: Advanced (including Drug Therapy) II1 Apr 2018MP66-19 PREDICTIVE VALUE OF INFLAMMATION-BASED PROGNOSTIC SCORES IN PATIENTS WITH METASTATIC RENAL CELL CARCINOMA TREATED WITH CYTOREDUCTIVE NEPHRECTOMY Hironori Fukuda, Toshio Takagi, Tsunenori Kondo, Kazuhiko Yoshida, Satoru Shimizu, and Kazunari Tanabe Hironori FukudaHironori Fukuda More articles by this author , Toshio TakagiToshio Takagi More articles by this author , Tsunenori KondoTsunenori Kondo More articles by this author , Kazuhiko YoshidaKazuhiko Yoshida More articles by this author , Satoru ShimizuSatoru Shimizu More articles by this author , and Kazunari TanabeKazunari Tanabe More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.1891AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The aim of the present study is to determine the most useful inflammation-based prognostic score for predicting survival in patients with metastatic renal cell carcinoma (mRCC) after cytoreductive nephrectomy (CN). METHODS We retrospectively analyzed the data of 152 patients who underwent CN for mRCC between 1986 and 2015. C-reactive protein (CRP), Glasgow prognostic score (GPS), neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), systemic inflammation response index (SIRI), and systemic immune-inflammation index (SII) were analyzed. Survival rates were compared using Cox proportional hazards regression models and predictive accuracy was evaluated using Harrell's concordance index (c-index). RESULTS Seven factors were significant predictors for survival in the multivariate analysis: age, Memorial Sloan-Kettering Cancer Center score, histology, sarcomatoid change, clinical nodal stage, brain metastasis, and liver metastasis (c-index 0.638). The c-index of these factors improved with the addition of an inflammation-based prognostic score: CRP (c-index: 0.672), GPS (c-index: 0.674), NLR (c-index: 0.685), LMR (c-index: 0.670), PLR (c-index: 0.666), SIRI (c-index: 0.652), and SII (c-index: 0.678). NLR provided the greatest improvement in the c-index. Additional multivariate analysis showed that NLR was an independent prognostic factor for survival rate (P < 0.0001). CONCLUSIONS NLR was most useful inflammation-based prognostic score for predicting survival in mRCC patients treated with CN. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e875-e876 Advertisement Copyright & Permissions© 2018MetricsAuthor Information Hironori Fukuda More articles by this author Toshio Takagi More articles by this author Tsunenori Kondo More articles by this author Kazuhiko Yoshida More articles by this author Satoru Shimizu More articles by this author Kazunari Tanabe More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...