MP64-04 SLCO2B1 HIGH EXPRESSED TUMOR IN HIGH GLEASON SCORE PROSTATE CANCER PATIENTS RECUR EARLIER AFTER RADICAL PROSTATECTOMY

Abstract

You have accessJournal of UrologyProstate Cancer: Basic Research & Pathophysiology II1 Apr 2018MP64-04 SLCO2B1 HIGH EXPRESSED TUMOR IN HIGH GLEASON SCORE PROSTATE CANCER PATIENTS RECUR EARLIER AFTER RADICAL PROSTATECTOMY Tomoaki Terakawa, Eriko Katsuta, Khurshid Guru, Kazuaki Takabe, and Masato Fujisawa Tomoaki TerakawaTomoaki Terakawa More articles by this author , Eriko KatsutaEriko Katsuta More articles by this author , Khurshid GuruKhurshid Guru More articles by this author , Kazuaki TakabeKazuaki Takabe More articles by this author , and Masato FujisawaMasato Fujisawa More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.2049AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Solute carrier organic anion (SLCO) genes encode organic anion transport proteins, which is a family of transport proteins that influx number of substrates into the cells including androgens. Among them, high expression of SLCO genes, including SLCO1B3 and SLCO2B1, has been shown to be associated with the resistance to androgen deprivation therapy in prostate cancer. However, the significance of the expression of SLCO genes in the recurrence after radical prostatectomy has not been elucidated. Here, we hypothesized that the high expression of these SLCO genes in human prostate cancer is associated with the recurrence after radical prostatectomy. METHODS Clinical and RNA-seq data were all obtained from the Cancer Genome Atlas (TCGA). Patients were classified as either high or low expression of SLCO1B3 or SLCO2B1 by the mean value. Survival analysis and gene set enrichment analysis (GSEA) was conducted between high and low expression group in whole cohort, as well as by Gleason score (GS=6, =7 or =8). RESULTS Patients were classified with the expression level of SLOC1B3 or SLCO2B1 by mean value of each gene. In overall survival, either of these genes was not related to survival. However, high expression group of SLCO2B1 showed significantly worse disease-free survival after radical prostatectomy (p=0.026), whereas the expression level of SLCO1B3 was not related to disease-free survival. The patients with higher Gleason score had significantly higher levels of SLCO2B1 expression (GS<6 vs GS=7; p=0.045, GS=7 vs GS>8; p=0.002). Significant difference in disease-free survival between high and low expression groups were only observed in the patients with GS=8 (p=0.005), and not in the patients with GS=7 (GS<6; p=0.640, GS=7; p=0.923). GSEA demonstrated that in the high expression group of SLCO2B1 enriched epithelial mesenchymal transition signaling related genes. CONCLUSIONS High expression of SLCO2B1 in the prostate cancer patients associated with the aggressive cancer characteristics and recurrence after radical prostatectomy, however no relation was found with the expression level of SLCO1B3. Furthermore, the high recurrence rate of the patients with high expression of SLCO2B1 may be able to be explained by its metastatic potential with up-regulated EMT pathways. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e851 Advertisement Copyright & Permissions© 2018MetricsAuthor Information Tomoaki Terakawa More articles by this author Eriko Katsuta More articles by this author Khurshid Guru More articles by this author Kazuaki Takabe More articles by this author Masato Fujisawa More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...