MP39-10 EFFECT OF OBESITY AND ADIPONECTIN SIGNALING IN PATIENTS WITH RENAL CELL CARCINOMA TREATED WITH SURGERY

Abstract

You have accessJournal of UrologyKidney Cancer: Basic Research I1 Apr 2015MP39-10 EFFECT OF OBESITY AND ADIPONECTIN SIGNALING IN PATIENTS WITH RENAL CELL CARCINOMA TREATED WITH SURGERY Ryuichi Itoh, Shintaro Narita, Mingguo Huang, Hiroshi Tsuruta, Susumu Akihama, Mitsuru Saito, Takamitsu Inoue, Norihiko Tsuchiya, Shigeru Satoh, and Tomonori Habuchi Ryuichi ItohRyuichi Itoh More articles by this author , Shintaro NaritaShintaro Narita More articles by this author , Mingguo HuangMingguo Huang More articles by this author , Hiroshi TsurutaHiroshi Tsuruta More articles by this author , Susumu AkihamaSusumu Akihama More articles by this author , Mitsuru SaitoMitsuru Saito More articles by this author , Takamitsu InoueTakamitsu Inoue More articles by this author , Norihiko TsuchiyaNorihiko Tsuchiya More articles by this author , Shigeru SatohShigeru Satoh More articles by this author , and Tomonori HabuchiTomonori Habuchi More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.760AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Obesity increases the risk for renal cell carcinoma (RCC), whereas obese patients appear to experience longer survival than non-obese patients. Inactivation of adiponectin signaling, which is a key regulator of obesity-related diseases, plays a role in the progression of RCC. Here we investigated the effect of obesity and adiponectin signaling in RCC patients treated with surgery. METHODS A total of 129 RCC patients treated with surgery were included in the analyses. Preoperative BMI, percentage of visceral adipose tissue (VAT) measured on CT scan, total adiponectin levels in the serum and perinephric adipose tissue condition medium by a specific ELISA, and intratumoral mRNA levels of AdipoR1 and AdipoR2 were statistically analyzed to assess the effect on pathological outcomes and survival. RESULTS Overweight and obese patients had a significantly lower grade cancer compared with normal weight patients in all patients and patients without metastasis (p = 0.003, p = 0.027, respectively). Disease-specific survival in overweight and obese patients was significantly longer compared with that in normal weight patients in all patients (p = 0.035), but not in patients without metastasis (p = 0.203). The percentage of VAT and serum adiponectin levels were not significantly associated with clinical outcomes of RCC patients. The mean adiponectin level of perinephric adipose tissue condition medium tended to be lower in patients with high grade RCC compared with healthy controls (p = 0.054). Although the mRNA expressions of AdipoR1 and AdipoR2 in tumors were not correlated with BMI and the VAT percentage, they were significantly lower in tumor tissues compared with normal renal tissues (p < 0.001, and p < 0.001, respectively). AdipoR1 expression in patients with high grade tumor was significantly lower compared with that in patients with low grade tumor (p = 0.030) and patients with sarcomatoid RCC had a significantly lower AdipoR1 expression compared with those with other histological subtypes (p = 0.001). CONCLUSIONS A high BMI may be associated with a better pathological outcome and survival in RCC patients treated with surgery. Impaired adiponectin secretion from enlarged adipose tissues and the inactivation of the intratumoral adiponectin receptor may be involved in RCC progression. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e457-e458 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Ryuichi Itoh More articles by this author Shintaro Narita More articles by this author Mingguo Huang More articles by this author Hiroshi Tsuruta More articles by this author Susumu Akihama More articles by this author Mitsuru Saito More articles by this author Takamitsu Inoue More articles by this author Norihiko Tsuchiya More articles by this author Shigeru Satoh More articles by this author Tomonori Habuchi More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...