MP35-06 STATIN USE IS NOT DETRIMENTAL TO SEMEN PARAMETERS IN SUBFERTILE MEN

Abstract

You have accessJournal of UrologyInfertility: Epidemiology & Evaluation II1 Apr 2017MP35-06 STATIN USE IS NOT DETRIMENTAL TO SEMEN PARAMETERS IN SUBFERTILE MEN James M. Hotaling, Sorena Keihani, James R. Craig, Chong Zhang, Angela P. Presson, Jeremy B. Myers, William O. Brant, Kenneth I. Aston, Benjamin R. Emery, and Douglas T. Carrell James M. HotalingJames M. Hotaling More articles by this author , Sorena KeihaniSorena Keihani More articles by this author , James R. CraigJames R. Craig More articles by this author , Chong ZhangChong Zhang More articles by this author , Angela P. PressonAngela P. Presson More articles by this author , Jeremy B. MyersJeremy B. Myers More articles by this author , William O. BrantWilliam O. Brant More articles by this author , Kenneth I. AstonKenneth I. Aston More articles by this author , Benjamin R. EmeryBenjamin R. Emery More articles by this author , and Douglas T. CarrellDouglas T. Carrell More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.1096AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Data from animal studies and small trials show conflicting results regarding the effects of statins on semen quality. Evidence is even more limited in subfertile patients. We aimed to assess the effects of statin use on semen parameters. To investigate this, we retrospectively compared semen parameters in statin users vs. non-users in subfertile men. METHODS From 2002-2013, we reviewed data from 12257 subfertile men visited at our fertility clinic. Patients who reported using any statin drugs for >3 months before semen sample collection were identified. Data on patient age, medication use, and conventional semen parameters were extracted. 7698 subfertile men taking no medications served as controls. Patients who were using any known spermatotoxic medications were excluded from the study. Variables with non-normal distributions (concentration, total count, and total motile sperm count) were log-transformed for analyses and the corresponding coefficients were presented as ratios. Linear mixed effect regression models were used to test the effects of statin use on semen parameters adjusting for age. The model coefficients, 95% confidence intervals (CIs) and p-values were reported, and statistical significance was assessed at the 0.05 level. RESULTS A total of 109 patients were identified taking statins. Mean age was 38.3 (standard deviation: 7.3). Estimates from the age-adjusted regression model are presented in Table-1. Ejaculate volume was 0.3 ml lower (95% CI: -0.58, -0.02 ml, p-value=0.04) and sperm viability was 4.52% higher (CI: 1.65%, 7.39 %, p-value=0.002) in statin users compared to controls. CONCLUSIONS Statin use was not adversely associated with semen parameters other than semen volume in subfertile patients. However, this should be interpreted cautiously given the limited sample size and retrospective nature of this study. Additional studies are needed to confirm these findings. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e459 Advertisement Copyright & Permissions© 2017MetricsAuthor Information James M. Hotaling More articles by this author Sorena Keihani More articles by this author James R. Craig More articles by this author Chong Zhang More articles by this author Angela P. Presson More articles by this author Jeremy B. Myers More articles by this author William O. Brant More articles by this author Kenneth I. Aston More articles by this author Benjamin R. Emery More articles by this author Douglas T. Carrell More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...