Abstract
Methods Peripheral blood eosinophils were incubated for 4 days with decreasing dilutions of MP29-02* (from 1:10 to 1:10 times), equivalent dilutions of FP (7.3x10M to 10M) or AZ (2.4x10M to 10M) prior to the addition of Epithelial Cell culture Media (ECM) from nasal mucosa (NM). Eosinophil survival was assessed by Trypan blue dye exclusion. Results are expressed as percentage (mean ± SEM) of eosinophil survival compared to control (100%).
Highlights
MP29-02* has demonstrated significant clinical effects in AR compared to these drugs in monotherapy
MP29-02* reduces eosinophil survival induced by epithelial cell secretions from nasal mucosa
At day 3, MP29-02* significantly inhibited eosinophil survival induced by Epithelial Cell culture Media (ECM) from dilution 1:102 (13.8±1.5%, N=6) to dilution 1:105 (58.8±10.8%, N=6), compared to ECM (100%)
Summary
MP29-02* reduces eosinophil survival induced by epithelial cell secretions from nasal mucosa. From The 10th Symposium of Experimental Rhinology and Immunology of the Nose (SERIN 2015) Stockholm, Sweden. From The 10th Symposium of Experimental Rhinology and Immunology of the Nose (SERIN 2015) Stockholm, Sweden. 19-21 February 2015
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
