MP28-05 PHENOTYPING MEN WITH BENIGN PROSTATIC HYPERPLASIA BASED ON LUTS QUESTIONNAIRES AND BLADDER DIARIES

Abstract

You have accessJournal of UrologyBenign Prostatic Hyperplasia: Epidemiology & Evaluation (MP28)1 Sep 2021MP28-05 PHENOTYPING MEN WITH BENIGN PROSTATIC HYPERPLASIA BASED ON LUTS QUESTIONNAIRES AND BLADDER DIARIES Lakshay Khosla, Philip Lee, Kevin Rychik, Max Edeson, Wade Bushman, and Jerry G Blaivas Lakshay KhoslaLakshay Khosla More articles by this author , Philip LeePhilip Lee More articles by this author , Kevin RychikKevin Rychik More articles by this author , Max EdesonMax Edeson More articles by this author , Wade BushmanWade Bushman More articles by this author , and Jerry G BlaivasJerry G Blaivas More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002025.05AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Men with Benign Prostatic Hyperplasia (BPH) may exhibit normal urine output, oliguria, or polyuria. The etiologies of polyuria have been previously investigated. This study was done to quantify clinical differences based on urinary output and test whether oliguria results from a patient-directed effort to reduce fluid intake to ameliorate lower urinary tract symptoms (LUTS). Specifically, we postulated that oliguria would be associated with more severe LUTS scores. METHODS: A retrospective analysis was performed utilizing a database for patients who completed a 24-hour bladder diary (24HBD) and the LUTS questionnaire from 2015 through 2019. Data on clinical diagnosis, demographics, uroflow (Q), post-void residual urine (PVR), and prostate size was obtained from the EMR. Patients with a clinical diagnosis of BPH with complete data were included. Patients were divided into three urinary phenotypes based on urine output: normal (>1 - <2500 L/24 H), oliguria (<1 L/24 H), and polyuria (>2.5 L/24 H).The data was analyzed using SPSS statistics software by utilizing one-way MANOVA, one-way ANOVA and Tukey’s HSD post-hoc tests. RESULTS: Of the 139 men in the database with BPH, 124 (mean age ± SD, 65.3 ± 11.9 years) had complete data available. Of these, 85 had normal urine output (69%), 14 had oliguria (11%), and 25 had polyuria (20%). Prostate size data was available for 45 men. There was no difference in the LUTSS or any of its subscores amongst the 3 groups. However, compared to the polyuria group, the oliguria group exhibited lower mean 24 hour voided volumes (24H VV), max voided volumes (MVV), daytime voids, total voids, maximum flow rate (Qmax), voided volume at Qmax, and PVR (Table 1). CONCLUSIONS: Our hypothesis was rejected; LUTS scores amongst men with oliguria were no different from LUTS scores amongst men with polyuria or normal 24H VV. However, men with oliguria had lower 24H VV, MVV, total voids, Qmax and PVR compared to men with polyuria. Differences in parameters demonstrate a need for the development of precise nomenclature for BPH phenotypes. To determine whether oliguria in BPH results from a patient’s self-restriction of fluid intake to mitigate LUTS that would otherwise be present, the patient’s role in managing symptoms should be investigated. Source of Funding: None © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e482-e482 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Lakshay Khosla More articles by this author Philip Lee More articles by this author Kevin Rychik More articles by this author Max Edeson More articles by this author Wade Bushman More articles by this author Jerry G Blaivas More articles by this author Expand All Advertisement Loading ...