MP16-04 THE ROLE OF G8 SCREENING TOOL IN THE ASSESSMENT OF SURGICAL OUTCOME OF ELDERLY PATIENTS (= 75 Y.O.) WITH HIGH-RISK PROSTATE CANCER: A PILOT STUDY

Abstract

You have accessJournal of UrologyProstate Cancer: Localized: Surgical Therapy III1 Apr 2018MP16-04 THE ROLE OF G8 SCREENING TOOL IN THE ASSESSMENT OF SURGICAL OUTCOME OF ELDERLY PATIENTS (= 75 Y.O.) WITH HIGH-RISK PROSTATE CANCER: A PILOT STUDY Kazuhito Matsushita, Jaspreet Sandhu, Shigeo Horie, Fumiyasu Endo, Masaki Shimbo, Kazutaka Narimoto, and Kazunori Hattori Kazuhito MatsushitaKazuhito Matsushita More articles by this author , Jaspreet SandhuJaspreet Sandhu More articles by this author , Shigeo HorieShigeo Horie More articles by this author , Fumiyasu EndoFumiyasu Endo More articles by this author , Masaki ShimboMasaki Shimbo More articles by this author , Kazutaka NarimotoKazutaka Narimoto More articles by this author , and Kazunori HattoriKazunori Hattori More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.538AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The impact of prostate cancer (PCa) in the elderly depends largely on the aggressiveness of the disease and the morbidity of treatment versus the life-expectancy of the patient. The advent of robot-assisted radical RP (RARP) and the decreasing morbidity associated with this procedure has made prostatectomy a much more approachable procedure for many men. G8 screening tool is a robust geriatric tool to identify a geriatric risk profile and for prediction of functional decline and prognostic information for overall survival. We evaluated the role of G8 screening tool in the assessment of the outcome of elderly patients (≥ 75 y.o.) who underwent RARP for high-risk PCa. METHODS We prospectively enrolled 41 men ≥ 75 years of age with high-risk PCa treated with RARP and extended pelvic lymph node dissection (ePLND). Age, PSA, BMI, Charlson Comorbidity Index (CCI) and pre-operative pad usage were recorded for each patient. G8 screening tool was administered to each patient before surgery. Clavien-Dindo complications (CDC) scoring system was used to report postoperative complications. Pad usage was used as a measure of continence and recorded at 6 months. Patients wearing no pads were considered continent. We used logistic regression to identify the role of G8 score in predicting postoperative complications and continence recovery at 6 months. RESULTS Mean age was 77 (IQR 76, 79) years old. Comorbidity factors included: 1 patients (2.4%) with CCI > 3 points, 10 patients (24.3%) with DM, 21 patients (51.2%) with HTN. Twenty patients had bilateral or unilateral nerve sparing RARP. G8 screening tool < 15 points was found in 16 patients (39%). In all, 36.5% (15/41) had postoperative complications and 42% (16/38) regained continence at 6 months. CDC ≥ 3 was present in 1 patient (2.4%). The mean score of G8 screening tool was 13.8 in patients that developed postoperative complications compared to a mean score of 15.6 in patients that did not (p<0.001). Only G8 score was independently predictive of continence recovery at 6months (p=0.005 OR 2.82 (95% CI 1.36-5.85)) and postoperative complications (p=0.001 OR 0.05 (95% CI 0.01-0.31)) on multivariate analysis. CONCLUSIONS G8 screening tool appears to be an effective and useful instrument for predicting the risk of complications and continence recovery in elderly patients who undergo RARP and ePLND. However, further investigations will be necessary to confirm the benefit of this tool as a risk-stratifying insturment. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e198 Advertisement Copyright & Permissions© 2018MetricsAuthor Information Kazuhito Matsushita More articles by this author Jaspreet Sandhu More articles by this author Shigeo Horie More articles by this author Fumiyasu Endo More articles by this author Masaki Shimbo More articles by this author Kazutaka Narimoto More articles by this author Kazunori Hattori More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...