MP10-06 RISK FACTORS FOR NEPHROLITHIASIS IN 24-HOUR URINE STUDIES OF PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE (NAFLD)

Abstract

You have accessJournal of UrologyCME1 Apr 2023MP10-06 RISK FACTORS FOR NEPHROLITHIASIS IN 24-HOUR URINE STUDIES OF PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE (NAFLD) Michelle Chen, Alex Nourian, Johnathan Drevik, Eric Ghiraldi, and Justin Friedlander Michelle ChenMichelle Chen More articles by this author , Alex NourianAlex Nourian More articles by this author , Johnathan DrevikJohnathan Drevik More articles by this author , Eric GhiraldiEric Ghiraldi More articles by this author , and Justin FriedlanderJustin Friedlander More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003225.06AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Nonalcoholic fatty liver disease (NAFLD) has been suggested to be an independent risk factor for renal stone disease by several studies. We aimed to identify abnormalities on 24-hour urine collection in this patient population. METHODS: 24-hour urine collections from a single tertiary care center were retrospectively reviewed from May 2014 to May 2021. Univariate analysis was performed using Chi-square test and unpaired T-test for categorical and continuous variables, respectively. A multivariable logistic regression was performed controlling for age, body mass index (BMI), diabetes mellitus (DM). RESULTS: 98 (24%) of 406 patients who met inclusion criteria were identified to have radiographic hepatic steatosis. There were no differences in baseline characteristics between groups including age, race, and gender. On univariate analysis, patients with NAFLD had decreased urinary pH (5.88 vs 6.06, p=0.02), elevated urinary oxalate (40 vs 36, p=0.04), calcium (219 vs 186, p=0.02) and sodium (185 vs 163, p=0.02) relative to those who did not have fatty infiltration of the liver on imaging. After controlling for DM and obesity as defined as BMI≥30, no 24-hour urine abnormalities were identified. CONCLUSIONS: After adjusting for confounding factors, patients with hepatic steatosis did not have identifiable abnormalities in their 24-hour urine studies. Increased risk of nephrolithiasis in patients with NAFLD is likely related to contributors of metabolic syndrome such as diabetes and obesity. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e116 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Michelle Chen More articles by this author Alex Nourian More articles by this author Johnathan Drevik More articles by this author Eric Ghiraldi More articles by this author Justin Friedlander More articles by this author Expand All Advertisement PDF downloadLoading ...