MP06-16 PREVALENCE AND CLONALITY OF SYNCHRONOUS PRIMARY CARCINOMAS IN THE BLADDER AND PROSTATE

Abstract

You have accessJournal of UrologyBladder Cancer: Epidemiology & Evaluation I1 Apr 2018MP06-16 PREVALENCE AND CLONALITY OF SYNCHRONOUS PRIMARY CARCINOMAS IN THE BLADDER AND PROSTATE Ruiyun Zhang, Ying Jing, Wei Xue, Yiran Huang, Guanglei Zhuang, and Haige Chen Ruiyun ZhangRuiyun Zhang More articles by this author , Ying JingYing Jing More articles by this author , Wei XueWei Xue More articles by this author , Yiran HuangYiran Huang More articles by this author , Guanglei ZhuangGuanglei Zhuang More articles by this author , and Haige ChenHaige Chen More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.208AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Incidental prostate adenocarcinoma (IPCa) has been frequently discovered during postoperative histopathological evaluation of radical cystoprostatectomy specimens in patients with muscle-invasive bladder cancer (MIBCa). However, a conclusive investigation is currently lacking with regard to the clinical significance of IPCa and the clonal relatedness of IPCa and MIBCa. METHODS Here, we performed a large retrospective single-center review of 919 MIBCa cases and an additional meta-analysis containing a total of 19,868 individuals who underwent radical cystectomy for bladder cancer. As a complementary approach, we sampled thirteen cases of synchronous BCa and IPCa (RJBC1-13) and performed whole-exome sequencing on matched bladder and prostate tumors with adjacent normal bladder tissues as controls. Furthermore, RESULTS IPCa was detected in 67 of 919 MIBCa patients (7.3%), which was significantly associated with greater age. A lower prevalence was observed in Asian populations (19.387 ± 3.277%) as compared to non-Asian countries (31.765 ± 2.284%), presumably due to different rates of prostate cancer occurrence. Whole-exome sequencing on matched MIBCa and IPCa samples unambiguously revealed independent clonal origins of the synchronous tumors. MIBCa and IPCa lesions from each patient displayed distinctive genomic abnormalities and unrelated mutational signatures of single nucleotide variations, indicating disparate mutational processes underlying bladder and prostate oncogenesis. CONCLUSIONS These findings provide important insights into the incidental nature of prostate adenocarcinoma in patients with bladder cancer and suggest that the two concurrent diseases can be managed separately. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e58 Advertisement Copyright & Permissions© 2018MetricsAuthor Information Ruiyun Zhang More articles by this author Ying Jing More articles by this author Wei Xue More articles by this author Yiran Huang More articles by this author Guanglei Zhuang More articles by this author Haige Chen More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...