MP04-03 ROLE OF ADIPONECTIN IN PROSTATE CANCER RISK AND THE PROLIFERATION OF PROSTATE CANCER.

Abstract

You have accessJournal of UrologyProstate Cancer: Epidemiology & Natural History I1 Apr 2016MP04-03 ROLE OF ADIPONECTIN IN PROSTATE CANCER RISK AND THE PROLIFERATION OF PROSTATE CANCER. Takashi Nitta, Hidekazu Koike, Hiroshi Mastui, Takeshi Miyao, Sota Kurihara, Yoshiyuki Miyazawa, Haruo Kato, Yoshitaka Sekine, Yasuhiro Shibata, Kazuto Ito, and Kazuhiro Suzuki Takashi NittaTakashi Nitta More articles by this author , Hidekazu KoikeHidekazu Koike More articles by this author , Hiroshi MastuiHiroshi Mastui More articles by this author , Takeshi MiyaoTakeshi Miyao More articles by this author , Sota KuriharaSota Kurihara More articles by this author , Yoshiyuki MiyazawaYoshiyuki Miyazawa More articles by this author , Haruo KatoHaruo Kato More articles by this author , Yoshitaka SekineYoshitaka Sekine More articles by this author , Yasuhiro ShibataYasuhiro Shibata More articles by this author , Kazuto ItoKazuto Ito More articles by this author , and Kazuhiro SuzukiKazuhiro Suzuki More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.1938AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Risk factors for protate cancer (PCA) include age, familial history, high-fat food ingestion, and obesity. Recent investigations revealed that several physiologically active substances including adiponectin (APN) is closely associated with the development of various types of cancer. APN is an anti-inflammatory cytokine produced by adipose tissue (a so-called adipokine), but unlike other adipokines, APN production decreases in obesity. Most of investigations showed an inverse association of APN levels and high-stage or high-grade PCA. However, some case control studies suggested a positive correlation between APN levels and PCA after adjustment for body mass index. So, we studied the association of prostate cancer risk with haplotype tagging single nucleotide polymorphisms (SNPs) of the adiponectin (ADIPOQ), and the functional role of adiponectin and adiponectin receptor 1 (ADIPOR1) in prostate cancer cells. METHODS none RESULTS Methods and Results: DNA samples in human from 198 cases and 122 benign prostatic hyperplasia were genotyped for ADIPOQ rs266729, rs822395, rs822396, rs1501299, and rs2241766 SNPs. We found that rs2241766 is associated with prostate cancer risk (figure 1). Next, we analyzed the functional role of adiponectin and ADIPOR1 in vitro and in vivo. In LNCaP cells, Adiponectin inhibited the cell proliferation in a dose-dependent manner. The cell proliferation was enhanced by siRNA against ADIPOR1 mRNA. In a nude mouse tumor xenograft model, high fat diet significantly increased the growth of LNCaP tumor. In between normal and high fat diet group, serum adiponectin concentrations did not change. However, the expression of ADIPOR1 mRNA in high fat diet group was down-regulated compared with that in normal fat diet group (figure 2). CONCLUSIONS Single nucleotide polymorphisms of the adiponectin is significantly associated with prostate cancer risk. Adiponectin and adiponectin receptor 1 may be associated with the proliferation of prostate cancer. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e28 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Takashi Nitta More articles by this author Hidekazu Koike More articles by this author Hiroshi Mastui More articles by this author Takeshi Miyao More articles by this author Sota Kurihara More articles by this author Yoshiyuki Miyazawa More articles by this author Haruo Kato More articles by this author Yoshitaka Sekine More articles by this author Yasuhiro Shibata More articles by this author Kazuto Ito More articles by this author Kazuhiro Suzuki More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...