MP03-18 A NOVEL METHOD FOR DERIVING BLADDER PROVOKED COMPLIANCE FROM ABDOMINAL COMPRESSIONS DURING ULTRASOUND URODYNAMICS

Abstract

You have accessJournal of UrologyCME1 Apr 2023MP03-18 A NOVEL METHOD FOR DERIVING BLADDER PROVOKED COMPLIANCE FROM ABDOMINAL COMPRESSIONS DURING ULTRASOUND URODYNAMICS Julia Smolen, Chris Keshishian, Adam J. Vossenberg, Sarah Kodama, Ria Khandpur, Jared Dunlap, Abraham Alattar, Isabelle Pummill, Gabrielle Grob, Mina P. Ghatas, Linda S. Burkett, Lauren N. Siff, Adam P. Klausner, and John E. Speich Julia SmolenJulia Smolen More articles by this author , Chris KeshishianChris Keshishian More articles by this author , Adam J. VossenbergAdam J. Vossenberg More articles by this author , Sarah KodamaSarah Kodama More articles by this author , Ria KhandpurRia Khandpur More articles by this author , Jared DunlapJared Dunlap More articles by this author , Abraham AlattarAbraham Alattar More articles by this author , Isabelle PummillIsabelle Pummill More articles by this author , Gabrielle GrobGabrielle Grob More articles by this author , Mina P. GhatasMina P. Ghatas More articles by this author , Linda S. BurkettLinda S. Burkett More articles by this author , Lauren N. SiffLauren N. Siff More articles by this author , Adam P. KlausnerAdam P. Klausner More articles by this author , and John E. SpeichJohn E. Speich More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003214.18AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Bladder wall response to stretch is measured through compliance, and during urodynamics (UDS), “filling compliance” is calculated as Δvolume/Δpressure. The objective of this study was to use ultrasound (US) during UDS to derive a novel provoked compliance metric in response to abdominal bladder compressions, instead of filling, and correlate this with participant characteristics and filling compliance. METHODS: Individuals indicated for UDS were enrolled in a prospective IRB-approved study. Participants’ bladders were filled to ∼50% capacity during UDS and filling was paused. The US probe was used to perform 5 sec compressions of the bladder 5 times to ∼50% of its anterior-posterior diameter, with 5 sec between compressions. One transverse abdominal US image captured before compression and one at the maximum compression pressure were analyzed. Tracing of each transverse bladder wall image and the ImageJ circularity function (Figure 1AB) were used to quantify bladder circularity. Compression induced Δcircularity/Δpressure was used to calculate provoked compliance. Filling compliance was also calculated, and age and BMI data were collected. RESULTS: Data from 31 women were analyzed in groups ≤60 and >60 years of age. A wider range of provoked compliance values was found in women >60 (Figure 1C, above horizontal line). Provoked compliance between 0.006 and 0.022 cm-H2O-1 was demonstrated in 12/13 (92%) of women <60 years of age, but only 5/18 (28%) of women >60 years (Figure 1C), indicating a significant association of age with provoked compliance (Fisher’s exact, p<0.05). There was no identified association between filling compliance or BMI and provoked compliance. CONCLUSIONS: Provoked compliance in response to bladder compression was quantified using a novel method, and women >60 demonstrated altered provoked compliance. Future studies connecting provoked compliance and specific types of bladder dysfunction are needed to demonstrate key relationships. Source of Funding: NIH R01DK101719, NSF REU 1852116, VCU School of Medicine Summer Research Fellowship © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e30 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Julia Smolen More articles by this author Chris Keshishian More articles by this author Adam J. Vossenberg More articles by this author Sarah Kodama More articles by this author Ria Khandpur More articles by this author Jared Dunlap More articles by this author Abraham Alattar More articles by this author Isabelle Pummill More articles by this author Gabrielle Grob More articles by this author Mina P. Ghatas More articles by this author Linda S. Burkett More articles by this author Lauren N. Siff More articles by this author Adam P. Klausner More articles by this author John E. Speich More articles by this author Expand All Advertisement PDF downloadLoading ...