Abstract
Mouse granulated metrial gland (GMG) cells are maternal, cytotoxic cells found in the uterine wall in pregnancy. In vivo, they are cytotoxic to layer 1 labyrinthine placental cells. In an in vitro system, granulated metrial gland cells are highly cytotoxic to Wehi 164 fibrosarcoma cells. In this study the role of interleukin (IL)-3 and tumour necrosis factor (TNF)-alpha in granulated metrial gland cell cytotoxic activity was investigated. Chromium-release cytotoxicity assays using mouse metrial gland effector cells and Wehi 164 target cells with the addition of IL-3 or an antibody to TNF-alpha. An antibody to TNF-alpha reduced the level of cytotoxic activity. IL-3 had no effect on the level of cytotoxicity. Mouse granulated metrial gland cells kill using a TNF-alpha mediated mechanism which is independent of IL-3 stimulation.
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Schedule a callMore From: American journal of reproductive immunology (New York, N.Y. : 1989)
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