Abstract
Botulinum neurotoxin (BoNT) has emerged as a major therapeutic advance in the treatment of many disorders, affecting motor and non-motor systems. It has applications in numerous medical specialties, including neurology, rehabilitation medicine, ophthalmology, otolaryngology, gastroenterology, orthopedics, dermatology, and urology. The use of BoNT for pain disorders is an emerging and active area of interest. A task force of the Technology and Therapeutics Assessment Committee of the American Academy of Neurology performed a literature search for relevant, fully published, peer-reviewed articles related to clinical use of BoNT for neurological disorders. The panel was comprised of specialists with experience in the therapeutic use of BoNT for the indications under consideration or with expertise in guideline methodology. Authors reviewed, abstracted, and classified papers based on AAN criteria (Class I–IV). This lecture summarizes the evidence supporting the use of BoNT in neurological disorders, including adult and childhood spasticity and selected movement disorders.
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