Motor control and reward-related behavior triggered by dopaminergic modulation

Abstract

Event Abstract Back to Event Motor control and reward-related behavior triggered by dopaminergic modulation Elisa Pozuelo Fernández1*, Patricia Bonnavion1, Serge N. Schiffmann1 and Alban De Kerchove D'Exaerde1 1 Université libre de Bruxelles, Laboratory of Neurophysiology, Belgium The contributions of dopaminergic neurons in locomotion and reward are traditionally attributed to the nigrostriatal and mesolimbic pathways, respectively. Dopaminergic neurons projecting from the Substantia nigra pars compacta to the dorsal Striatum are known to influence locomotor activity, whereas the dopaminergic projections from the Ventral Tegmental Area to the ventral Striatum (Nucleus Accumbens) are important in reward processes. Here, using chemo- and opto-genetic approaches to control and activate differentially these specific dopaminergic populations, we seek to decipher and characterize their respective contributions in locomotion and reward. Moreover, the classical model explaining the dual role of DA in movement and reward posits that rapid phasic signaling (~400-ms bursts) drives reward-related behavior, whereas slow and continuous variations in firing (sec to min) modulate movement. Optogenetics sub-second precision allows us to address these questions onto midbrain DA sub-groups. Our results suggest that different midbrain DA modulation can differentially trigger motor control and reward-related behavior. Keywords: Dopamine, reward system, motor control, optogenetics and DREADDs, mouse models Conference: 12th National Congress of the Belgian Society for Neuroscience, Gent, Belgium, 22 May - 22 May, 2017. Presentation Type: Poster Presentation Topic: Cognition and Behavior Citation: Pozuelo Fernández E, Bonnavion P, Schiffmann SN and De Kerchove D'Exaerde A (2019). Motor control and reward-related behavior triggered by dopaminergic modulation. Front. Neurosci. Conference Abstract: 12th National Congress of the Belgian Society for Neuroscience. doi: 10.3389/conf.fnins.2017.94.00067 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 24 Apr 2017; Published Online: 25 Jan 2019. * Correspondence: Mrs. Elisa Pozuelo Fernández, Université libre de Bruxelles, Laboratory of Neurophysiology, Brussels, Belgium, epozuelo@ulb.ac.be Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Elisa Pozuelo Fernández Patricia Bonnavion Serge N Schiffmann Alban De Kerchove D'Exaerde Google Elisa Pozuelo Fernández Patricia Bonnavion Serge N Schiffmann Alban De Kerchove D'Exaerde Google Scholar Elisa Pozuelo Fernández Patricia Bonnavion Serge N Schiffmann Alban De Kerchove D'Exaerde PubMed Elisa Pozuelo Fernández Patricia Bonnavion Serge N Schiffmann Alban De Kerchove D'Exaerde Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.