Abstract
The thymic morphometry analysis was used for determining apoptosis and atrophy of the thymus of eight puppies inoculated with canine distemper virus (CDV). Three healthy dogs were used as negative controls. Sections, 5µm thick, were stained by HE and Shorr, and the latter were evaluated by morphometry. CDV nucleoprotein was detected by immunohistochemistry. Morphometric results confirmed lymphoid hypotrophy in CDV inoculated dog thymuses, more stroma, less parenchyma and higher apoptotic index/field than negative control (not inoculated) puppies. Apoptosis plays a role in the mechanism of thymus atrophy that develops in canine distemper.
Highlights
Canine distemper (CD) is an acute or subacute highly contagious febrile disease that may include respiratory, gastrointestinal and central nervous system disorders
The disease is caused by the canine distemper virus (CDV)
Thymus hypotrophy was evident in all inoculated puppies at the 10th day after inoculation
Summary
Canine distemper (CD) is an acute or subacute highly contagious febrile disease that may include respiratory, gastrointestinal and central nervous system disorders. The disease is caused by the canine distemper virus (CDV) CDV infection causes lymphopenia and immunosuppression in dogs during the early phase of the disease (Iwatsuki et al, 1995; Moro et al, 2003b).
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