Morphological predictors of aggressive course of STH secreting pituitar y adenomas in patients with acromegaly

Abstract

Acromegaly is a rare disease that occurs against the background of existing pituitary adenoma, leading to disability and high mortality as a result of secondary complications caused by chronic hyperproduction of IGF-1. The main predictors of disease recurrence and ineffectiveness of surgical treatment currently remain the size of the tumor, the presence of tumor invasion into the cavernous sinus, high preoperative levels of growth hormone and IGF-1. According to the literature, surgical remission is achieved on average in 57% -89% of patients. The search for factors of a negative outcome of surgical treatment remains an urgent problem. Based on our experience of surgical treatment of 144 patients with acromegaly, we analyzed the sex and age differences of patients and compared them with the outcomes of treatment after a year of follow-up. The male sex in our study was a risk factor for suprasellar tumor spread, the detection of a residual tumor a year after surgical treatment. However, there were in the relapse of the disease after a year of follow-up. The younger age of patients is associated with high tumor invasion into the cavity of the cavernous sinus and a low frequency of remission of the disease during the year of follow-up.