Abstract
We report here studies on the structure of the thymus in 108 Wistar rats with different predicted levels of resistance to emotional stress in experimentally modeled intracerebral hemorrhage. Changes in the thymus occurring in intracerebral hemorrhage were associated with both the stereotypical stress response and the development of an immune response to damaged brain tissue: there were decreases in relative thymus weight and the cortical:medullary index, along with increases in the volume proportions of the capsule and connective tissue septa; a vascular reaction was also noted, with stasis, diapedesis, and perivascular edema. These changes were most marked in rats with a predisposition to emotional stress.
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