Abstract
A study of the influence of chronic alcohol intoxication, constant illumination and their combined effects on the morphofunctional state of the rat liver and the circadian rhythms (CR) of the studied parameters of the organism was carried out. It was found that both alcohol and constant illumination caused significant changes in the structure of the liver, as well as in the circadian rhythmicity of micromorphometric parameters of hepatocytes, ALT, and total and direct bilirubin rhythms; however, the combined effects of ethanol and constant illumination had the most significant effect on the studied parameters of the organism. These two factors caused disturbances in the circadian rhythms of the micromorphometric parameters of hepatocytes, disruption of the circadian rhythms of total protein, albumin, AST, ALT, and direct and total bilirubin, as well as disturbances in the expression and rhythmicity of the studied clock genes against a background of the development of an inflammatory process in the liver.
Highlights
Alcohol abuse is one of the most important health and social problems in modern society
The morphological pattern of the liver in the rats of the control group corresponded to the age norm, i.e., the liver had a preserved structure of hepatic cords, composed of polygonal hepatocytes with a rounded, centrally located nucleus without signs of dystrophic changes and necrosis (Figure 1A)
The control staining with Sudan-III verified the presence of lipid drops in the cytoplasm of the hepatocytes in this group, which indicates the beginning of the development of fatty degeneration of the liver
Summary
Alcohol abuse is one of the most important health and social problems in modern society. Systematic alcohol consumption leads to disruption of the structure and function of the liver, which, in turn, alters the metabolism of other organs. Alcoholic liver disease (ALD) include several sequential clinical and morphological forms, which are stages of a single pathological process caused by prolonged alcohol use [1,2]. The rhythmicity of vital processes, which is one of the fundamental properties of living matter, includes periodic changes and the integration of various processes specific to biological systems at different levels of organization [3]. The presence of an organized rhythmic structure of biological processes provides the necessary order of their occurrence, which determines the maintenance of the functioning of body systems at an optimal level [6,7,8,9]
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