Abstract
Gestational diabetes mellitus (GDM) and preeclampsia (PE) are common pregnancy complications with similar risk factors. Although GDM is associated with PE, the exact mechanism underlying the association of these diseases is unclear. The aim of the work: to study morphofunctional and molecular changes in the placenta and peripheral blood both in PE and GDM. In the study, we evaluated local and systemic changes in the production of several placental proteins, markers of inflammation and metabolic disorders. Changes in villi expression of placental lactogen, trophoblastic β1-glycoprotein, placental alpha-1-microglobulin, and proteinase3 were noted in the groups of complicated pregnancies. The present study shows the similarity of the pathogenic mechanisms underlying PE and GDM.
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