Abstract
ABSTRACTBackground: Morinda citrifolia L. is widely used as a folk medicinal food plant to manage a panoply of diseases, though no concrete reports on its potential anti-obesity activity. This study aimed to evaluate the potential of M. citrifolia leaf extracts (MLE60) in the prevention of weight gain in vivo and establish its phytochemical profile.Design: Male Sprague-Dawley rats were divided into groups based on a normal diet (ND) or high fat diet (HFD), with or without MLE60 supplementation (150 and 350 mg/kg body weight) and assessed for any reduction in weight gain. Plasma leptin, insulin, adiponectin, and ghrelin of all groups were determined. 1H NMR and LCMS methods were employed for phytochemical profiling of MLE60.Results: The supplementation of MLE60 did not affect food intake indicating that appetite suppression might not be the main anti-obesity mechanism involved. In the treated groups, MLE60 prevented weight gain, most likely through an inhibition of pancreatic and lipoprotein activity with a positive influence on the lipid profiles and a reduction in LDL levels . MLE60 also attenuated visceral fat deposition in treated subjects with improvement in the plasma levels of obesity-linked factors . 1Spectral analysis showed the presence of several bioactive compounds with rutin being more predominant.Conclusion: MLE60 shows promise as an anti-obesity agents and warrants further research.
Highlights
There are four hundred million obese (body mass index (BMI) > 30 kg m−2) and 1.6 billion overweight (BMI = 25.0–29.9 kg m−2) people worldwide
The positive correlation between increased level of C-reactive protein (CRP) and obesity confirm the fact that this disease is a chronic inflammatory state, which can potentially lead to cardiovascular diseases [3]
Male Sprague-Dawley rats were divided into groups based on a normal diet (ND) or high fat diet (HFD), with or without two different doses (150 and 350 mg/kg body weight) of MLE60 supplementation and assessed for the prevention of weight gain
Summary
Overweight and obese people have an increased risk factor for diabetes, cardiovascular diseases, and certain cancers [1]. The positive correlation between increased level of C-reactive protein (CRP) and obesity confirm the fact that this disease is a chronic inflammatory state, which can potentially lead to cardiovascular diseases [3]. Both developed and developing nations have not been spared by this public health burden. Morinda citrifolia L. is widely used as a folk medicinal food plant to manage a panoply of diseases, though no concrete reports on its potential anti-obesity activity. This study aimed to evaluate the potential of M. citrifolia leaf extracts (MLE60) in the prevention of weight gain in vivo and establish its phytochemical profile
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