Abstract
Monoclonal anti-human T cell antibodies were tested by a modified PAP technique on frozen sections of human central nervous system (CNS) tissue from inflammatory and non-inflammatory conditions. It was found that whole T cells and T cell subset - T4+ (helper-induced)_ and T8+ (suppressor/cytotoxic) T cells - could could be differentiated specifically from other mononuclear cells and their these markers did not cross-react with human CNS tissue elements, particulary oligodendrocytes, under the same conditions. The lack of cross-reactivity between monoclonal antibodies to T cells and oligondendrocytes was further confirmed by double-labelling with an anti-galactocerebroside serum. It is concluded that in inflammatory condition like multiple sclerosis, monoclonal antibodies promise considerable elucidation of immunopathogenetic events.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
