Monitoring the induction of pilocarpine epilepsy in NEC rats

Abstract

Event Abstract Back to Event Monitoring the induction of pilocarpine epilepsy in NEC rats B. Cseri1*, A. Czurkó2, P. Baracskay1 and G. Juhász1 1 Eötvös Loránd Science University, Institute of Biology, Hungary 2 University of Szeged, Institute of Medical Chemistry, Hungary Pilocarpine epilepsy is a pharmacological model of chronic temporal lobe epilepsy. Pilocarpine is a muscarinic cholinergic agonist drug which can provoke epileptic seizure and status epilepticus (SE) in rats when administered systemically. We have monitored the progession of pilocarpine status epilepticus. During the spreading of SE different phases occur according to the Treiman-scale. These stages are characterized by electroencephalographical and behavioural features. Our aim was to investigate the correspondence of Treiman-stages and the features of visual evoked potentials (VEPs) during SE. VEPs can be used to assess the state of the central nervous system, as they undergo characteristic changes during absence seizures, sleep stages, coma, etc. Measurements were carried out in freely moving NEC (non-epileptic controll) rats. Electroretinogram, bilateral recording of evoked potentials in the visual cortex and a four-channel cortical EEG was used to record electroencephalographical changes. We used a ramping-up dose protocoll for pilocarpine treatment. Our results show that characteristic changes in VEP components can be observed. These changes are the effect of pilocarpine-treatment induced SE. We also observed persistent theta-rhythm in the EEG of animals which did not develop SE. According to recent data in the literature, theta-rhythm can be considered as an anti-epileptic feature in the nervous system. Keywords: disorders, Neuroscience Conference: 13th Conference of the Hungarian Neuroscience Society (MITT), Budapest, Hungary, 20 Jan - 22 Jan, 2011. Presentation Type: Abstract Topic: Disorders Citation: Cseri B, Czurkó A, Baracskay P and Juhász G (2011). Monitoring the induction of pilocarpine epilepsy in NEC rats. Front. Neurosci. Conference Abstract: 13th Conference of the Hungarian Neuroscience Society (MITT). doi: 10.3389/conf.fnins.2011.84.00106 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 03 Mar 2011; Published Online: 23 Mar 2011. * Correspondence: Dr. B. Cseri, Eötvös Loránd Science University, Institute of Biology, Budapest, Hungary, biocherry@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers B. Cseri A. Czurkó P. Baracskay G. Juhász Google B. Cseri A. Czurkó P. Baracskay G. Juhász Google Scholar B. Cseri A. Czurkó P. Baracskay G. Juhász PubMed B. Cseri A. Czurkó P. Baracskay G. Juhász Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.