Abstract
BACKGROUND: To increase public confidence in vaccine prevention and to actually assess the safety of vaccines against COVID-19, it is necessary to study the frequency and structure of adverse events after immunization in the post-registration period of vaccine use.
 AIM: To assess the frequency and structure of adverse events after immunization against COVID-19 among young people during the period of post-registration use of vaccines.
 MATERIALS AND METHODS: A single center cross-sectional study was conducted based on a questioning of 333 respondents aged 1825 years (76.88% female, 23.12% male). The questionnaire included 2 groups of questions: general and special (nature of post-vaccination reactions, history of COVID-19 disease before and after vaccination). Statistical processing of the results was carried out using standard Microsoft Office Excel 2016 software packages.
 RESULTS: The most common complaints after vaccination were soreness at the injection site (57.66%), weakness (54.65%) and body aches (24.92%). There were local and general/combined (weak, moderate, strong) reactions, they were observed in 30.93% of respondents after 1 dose and 45.35% after 2 doses. In the structure of reactions after the first immunization, general weak reactions (15.32%, p=0.001) were significantly more common than others, after the second local ones (21.92%, p 0.0001). A strong correlation was established between responses to the 1st and 2nd doses of the vaccine (r=0.94, p 0.0001). When studying the frequency and structure of post-vaccination reactions in sex groups and in those who had COVID-19 before vaccination and those who did not, no significant differences were found.
 CONCLUSIONS: The study found that among young people, the majority did not have objective reactions after immunization against a new coronavirus infection. General weak and local reactions were more common among the objective post-vaccination reactions.
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