Abstract
Mondor's disease is a rare, peculiar form of superficial thrombophlebitis which mainly affects the subcutaneous veins of the breast, anterior chest wall, neck, axilla, upper limbs and penis.In most cases, it presents with rapid development of a painful subcutaneous cord-like structure that later becomes less painful, but a fibrous band persists. Unfortunately, aetiology and management are not very clear, but it is a self-limiting condition in most cases.We are presenting a rare case of a patient who developed Mondor's disease in the antecubital fossa of the right arm following chemotherapy for breast cancer.
Highlights
Mondor's disease is a rare, peculiar form of superficial thrombophlebitis which mainly affects the subcutaneous veins of the breast, anterior chest wall, and rarely other parts including cervical region, axilla, upper limbs or the penis.While Faage was the first one to describe this condition in 1869, it is named after Henri Mondor, a French surgeon who gave this condition further characterization and described it as a syndrome of sclerosing superficial thrombophlebitis of the veins of the anterior thoracic wall in 1939 [1].The differential diagnosis of Mondor's disease, in general, varies according to the location of symptoms
We present a case of a 36-year-old lady who was diagnosed with right breast cancer
Authors suggested that the condition starts with an inflammatory response including, pain, swelling and redness at the site leading to superficial vein fibrosis, forming a cord-like structure that can be visible and palpable
Summary
Mondor's disease is a rare, peculiar form of superficial thrombophlebitis which mainly affects the subcutaneous veins of the breast, anterior chest wall, and rarely other parts including cervical region, axilla, upper limbs or the penis. The final postoperative histology showed a 30 mm grade III invasive ductal carcinoma, estrogen receptor (ER) 8, progesterone receptor (PR) 8, human epidermal growth factor receptor 2 (HER2) negative and sentinel node biopsy revealed a single non-cancerous lymph node (0/1) and her Nottingham Prognostic Index was 4.6 Her Oncotype Dx test results showed a high recurrence score, and she subsequently underwent adjuvant chemotherapy (Epirubicin, Cyclophosphamide, and Taxol). Her past medical history and family history were insignificant Seven months later, she presented with painful cord-like bands in her right cubital fossa. Examination revealed three mildly tender cord-like bands which were oriented longitudinally along the length of the arm Even though they were palpable and uncomfortable, they did not cause any restriction to the right elbow movement (Figure 1). The bands have not had any negative effect on the patient’s arm function at any point
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