Abstract
Three new compounds, monarubins A–C (1, 6 and 13), together with ten known compounds, including four alkaloids (2–5), two isocoumarins (7 and 8) and four polyketides (9–12), were isolated from marine shellfish-associated fungus Monascus ruber BB5. The structures were determined on the basis of the 1D and 2D NMR, MS, UV and IR data. The absolute configurations of compounds 3, 6 and 13 were determined by ECD calculations. The NMR data of compounds deoxyhydroxyaspergillic acid (3) and 2-hydroxy-6-(1-hydroxy-1-methylpropyl)-3-sec-buthylpyrazine (4) were first reported. All of the isolated compounds were evaluated for their cytotoxic activities against human nasopharyngeal carcinoma cell lines CNE1, CNE2, SUNE1 and HONE1 and hepatocellular carcinoma cell lines QGY7701 and HepG2. Monarubin B (6) displayed potent cytotoxicities against the cancer cell lines HepG2 and QGY7701 with IC50 values of 1.72 and 0.71 μΜ, respectively; lunatinin (7) showed moderate cytotoxic activities against the cancer cell lines HepG2, QGY7701 and SUNE1 with the IC50 values of 9.60, 7.12 and 28.12 μΜ, respectively.
Highlights
Since 1990, marine aquatic production in China has ranked first in the world, among them, edible marine shellfishes are exceeding 75% of the total output [1]
Compounds 1–13 were evaluated for their cytotoxic activity against six cancer cell lines, including four human nasopharyngeal carcinoma cell lines CNE1, CNE2, SUNE1 and HONE1 and two human hepatocellular cancer cell lines HepG2 and QGY7701
The marine fugus Monascus ruber BB5 was isolated from Meretrix meretrix collected from Hailing
Summary
Since 1990, marine aquatic production in China has ranked first in the world, among them, edible marine shellfishes are exceeding 75% of the total output [1]. A fungal strain Monascus ruber (collection number BB5) was isolated from the inner tissue of marine shellfish Meretrix meretrix collected from Hailing island, Yangjiang, China. Monascus as ruber in 1973, is considered as the most efficacious cholesterol and has been approved as a clinical prescription named lovastatin [8,17]. Considering distributed and more than 100 million prescriptions were written worldwide between the years 1988 the biodiversity and the huge metabolic potential, it is stillmetabolic worthwhile to investigate theworthwhile secondary andfungal. Considering fungal biodiversity and huge potential, it is still metabolites of the Monascus species and theirofbioactivities.
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